Recommended dose of tapentadol is 50 to 100 mg four to six hourly when required (100 to 400mg per day).

Tapentadol tablet are used to treat pain severe.

There was moderate‐quality evidence that people treated with tapentadol had at least 50% pain reduction.

Solid clinical data support the efficacy and safety of tapentadol in the treatment of OA-associated pain, in line with its pharmacological rationale.